4 edition of Molecular Cytogenic Analysis of Adipose Tissue Tumors With Chromosome 12Q13-Q15 Involvement found in the catalog.
Molecular Cytogenic Analysis of Adipose Tissue Tumors With Chromosome 12Q13-Q15 Involvement
Patrick F. J. Kools
by Coronet Books Inc
Written in English
|Series||Acta Biomedica Lovaniensia , No 149|
|The Physical Object|
|Number of Pages||183|
Adipose tissue neoplasm. Jump to navigation Jump to search. This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced. Home > Research > Cancer Cytogenetics. Cancer Cytogenetics "A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE." (MeSH ).
Summary. We analyzed DNA from primary breast cancers to assess amplification of the ERBB2 gene and loss of heterozygosity (LOH) on chromosome 17 using 4 polymorphic markers, and investigated the relationships of these genetic alterations to . The invention relates to the multi-tumor aberrant growth gene having the nucleotide sequence of any one of the strands of any one of the members of the High Mobility Group protein genes or LIM protein genes, including modified versions and derivatives thereof. The gene and its derivatives may be used in various diagnostic and therapeutic applications.
Nonrandom chromosome changes were observed, but no specific chromosome alterations were consistently found in tumor-derived CHEF cells. Although CHEF/16 cells are uniformly tumorigenic in nude mice, each of 10 uncloned tumor-derived populations from inocula of 10 2, 10 4, and 10 6 CHEF/16 cells consisted of only 1–3 stemlines. In this study, we report the cytogenetic analysis of a year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CDpositive soft tissue sarcoma of the thigh, which metas-tasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with positivities of CD99, vimentin.
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We were able to narrow down the region to approximately kb belonging to an area designated a multiple aberration region, because it also includes the breakpoints of leiomyomas, lipomas, and pleomorphic adenomas with 12q by: Immunohistochemically, the tumor cells did not reveal the expression of murine double-minute 2 (MDM2).
Cytogenetic analysis revealed a complex karyotype with several numerical and structural alterations, including 12q rearrangements. Spectral karyotyping demonstrated a duplication of chromosome segment 12qAuthor: Jun Nishio, Hiroshi Iwasaki, Terufumi Shibata, Kazuki Nabeshima, Masatoshi Naito.
Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification. Samaniego F(1), Rodriguez E, Houldsworth J, Murty VV, Ladanyi M, Lele KP, Chen QG, Dmitrovsky E, Geller NL, Reuter V, et al.
Author information: (1)Laboratory of Cancer Genetics, Sloan-Kettering Institute, New York, New by: Cytogenetic Studies of Adipose Tissue Tumors. Recurrent Reciprocal Translocation t(12;16)(q13;p11) in Myxoid Liposarcomas Claude Turc-Carel, Janusz Limon, Paola Dal Cin, Uma Rao, Constantine Karakousis, and Avery A.
Sandberg ABSTRACT: Detailed chromosome studies, briefly reported previously, from short-term cultures of tumor cells from myxoid liposarcomas are by: Cancer Genet Cytogenet 7.
Limon J, Dal Cin P, Sandberg AA (): Application of long term collagenase disaggre- gation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet (in pressl. Sandberg AA, Gibas Z, Saren E, Li FP, Limon J, Tebbi CK (): Chromosome abnormal- ities in two benign adipose by: Histologically, this tumor is rich in vascular structures and in collagen fibers and is of myxoid appearance.
Cytogenetic and molecular analysis was performed on a case of an aggressive angiomyxoma and revealed clonal karyotypic abnormalities. All 50 metaphases analyzed showed a translocation involving the chromosomal region 12q Molecular studies of familial and sporadic cylindromas have shownfrequent alterations at chromosome 16q that have recently been found tohouse the cylindromatosis gene (CYLD).
To determine the involvement of thechromosome 16q region in dermal analogue tumors, we performed loss ofheterozygosity analysis using microsatellite markers flanking the cylindromatosisgene locus in 21 sporadic dermal analogue salivary tumors. The remaining samples comprised 12 benign STT, four bone tumors, and 16 other tumors.
Recent molecular cytogenetic analysis demonstrated that the STS can be divided into two main categories of neoplasms: (i) sarcomas with specific genetic alterations characterized by either simple chromosomal translocations resulting in fusion genes (e.g.
EWSR1. INTRODUCTION Clonal cytogenetic abnormalities have been detected in diverse cancers, whereas, data are scanty on the karyotypes of clinically and histologically benign tumors.
We wish to report two histologically benign tumors of adipose tissue (lipoblastoma, fibrolipoma) with chromosome changes usually associated with malignant neoplasms.
Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Lipoma Article Literature Review in Cancer Genetics and Cytogenetics (2) May with 33 Reads. If it is necessary to hold a tissue sample overnight, please refrigerate.
Do not freeze. Formalin fixed tissues are not appropriate for chromosome analysis. However, paraffin embedded or formalin fixed tissues are accepted for FISH for Chromosome Abnormalities Common in Pregnancy Loss.
Sandberg AA, Gibas Z, Saren E, Li FP, Limon J, Tebbi CK () Chromosome abnormalities in two benign adipose tumors. Cancer Genet Cytogenet –61 PubMed CrossRef Google Scholar Sandros J, Stenman G, Mark J () Cytogenetic and molecular observations in human and experimental salivary gland tumors.
New Discriminative Chromosomal Marker in Adipose Tissue Tumors The Chromosome 8qq13 Region in Lipoblastoma Paola Dal Cin, Raf Sciot, Ivo De Wever, Boudewijn Van Damme, and Herman Van Den Berghe ABSTRACT: Specific chromosome abnormalities characterize benign and malignant adipose tissue tumors and are of great diagnostic and clinical importance.
Cancer Genet Cytogenet. May; 32 (1)– Vanni R, Lecca U. Involvement of the long arm of chromosome 12 in chromosome rearrangements of uterine leiomyoma. Cancer Genet Cytogenet. May; 32 (1)– Walter TA, Fan SX, Medchill MT, Berger CS, Decker HJ, Sandberg AA.
inv(12)(pq13) in an endometrial polyp. Introduction. Cytogenetic and loss of heterozygosity (LOH) studies demonstrated that deletions of the short arm of chromosome 3 (3p) occur at a high frequency in all forms of lung recently, comparative genomic hybridization (CGH) studies also detected recurrent decreases in the copy number of 3p 2, deletions are considered a critical event in pathogenesis, and the.
[From cytogenetics to cytogenomics of adipose tissue tumors: 1. Benign adipose tissue tumors]. Pedeutour F, Foa C. Bull Cancer, 89(), 01 Jul Cited by:. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Liposarcoma Article Literature Review in Cancer Genetics and Cytogenetics (1) December with EPB1 EPA EPA EPB1 EP B1 EP B1 EP B1 EP A EP A EP A EP B1 EP B1 EP B1 Authority EP European Patent Office Prior art keywords gt lt gene dna chromosome Prior art date Legal status (The legal status is an assumption and is not a legal conclusion.
Oncology Testing. Chromosome Analysis. also known as: Cancer Cytogenetics, Karyotyping, G -bands. TEST DESCRIPTION: Conventional cytogenetics (chromosome analysis) analyze the whole genome in a single assay. Developed over 50 years ago, this assay still plays a vital role in cancer diagnostics because it allows for simultaneous characterization of.
Tissue culture for tumor, Interpretation and report. w/modifier Chromosome analysis Chromosome analysis with 20 to 25 cells (if appropriate)- Chromosome analysis with >25 cells (if appropriate) Additional specialized banding technique (if appropriate).
Cytogenetic analysis of adipose tissue tumors, lipomas, and nine liposarcomas (LPS) showed the presence of a ring chromosome and/or a long marker chromosome in 10 cases with common.USA). The subsequent cytogenetic analysis and karyotype description followed the recommendations of the International System for Human Cytogenetic Nomenclature (9).
RNA extraction. Tumor tissue adjacent to that used for cyto-genetic analysis and histologic examination had been frozen and stored at ˚C from 4 tumors (cases ). Total RNA was.NISHIO et al: LIPOMATOUS TUMOR WITH DUPLICATION OF CHROMOSOME SEGMENT 12q also observed.
Immunohistochemically, the tumor cells were revealed to not express MDM2. The pathological diagnosis was lipomatous tumor with minimal nuclear atypia. A representative fresh tissue sample was obtained for cyto - genetic analysis.